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> Yogurt rose the most, followed by fresh fruit, nutrition bars and meat snacks.

I would guess that this is because people are replacing full-blown meals with smaller snacks. The meat snacks is probably because people are warned about losing muscle mass. Perhaps this affects yogurt consumption as well.

> Notably, about one-third of users stopped taking the medication during the study period.

This seems pretty high considering they're only following people for 6 months. I guess people are most likely to have side effects at the beginning, but I feel like I've not gotten the sense that a third of people bail within the first year, due to side effects or other reasons.





A common reason people quit is that they miss the pleasure that eating previously gave them.

I’ve lost 110 pounds on Zepbound and still absolutely love food. My relationship has changed with it substantially, though. I used to feel a strong urge to eat, often, and anything I could shovel down. I felt like I literally could never eat enough. I had terrible heartburn all the time. I’d eat a box of zebra cakes on the way home from the store. Something was very wrong with me. Right now I’m enjoying a homemade matzo ball soup with rotisserie chicken and homemade stock. It’s been absolutely life changing. I still eat zebra cakes sometimes, although far less, and I’m hard pressed to finish two, much less an entire box.

I was able to lose weight before but it always required adhering strictly to a diet, or I’d just gain all the weight back. I’m so indescribably happy to be able to go on long bike rides, work on my house without getting tired after 20 minutes, and I go to the gym regularly. All this happened after the weight loss, not before. I think a lot of things we think are causing obesity is mixed up — the obesity for me seemed to be causing the dysfunction in almost every facet of my life.


That's great it works for you. I was basing my comment on an article from a German newspaper that cites an obesity researcher who said that lost pleasure from eating is a major reason people quit: https://archive.ph/UnjMe The evidence still appears anecdotal. They don't cite any studies that bear this out.

Most people quit, because it doesn't work:

https://www.theguardian.com/wellness/2025/aug/14/ozempic-wei...

I hoped it will finally shut up those stuck on the dogma, but it seems the denial is far too strong, and nothing will change.

And yes, it is a dogma, because no kind of evidence no matter how strong makes people like you reconsider.


From your link:

> “The meds are highly effective for a majority of patients but there is still a percentage who don’t lose a clinically significant percentage of body weight. Everyone’s physiology is a little different,” – Veronica Johnson MD, an obesity medicine specialist in Chicago

> He explained that for someone who is overweight, shedding even a small amount of weight can improve heart and kidney function

And, the Guardian is exactly the kind of outlet that would publish "woe is me, it doesn't work for me" stories, as it's their target audience.

It's a tool - it can be a force multiplier if you also make other changes. If you just take the jab and do no exercise and continue eating bad, weight loss will be minimal.

Yes it's been oversold – just like almost any other product/service that ha an advertising budget. That doesn't mean it "doesn't work" for everyone.

Does your car 'not work' because you can't attract those extremely attractive ladies in the street which are often featured in the adverts?


It also cites a study which says that the average loss is 5%. That isn't what most people imagine as "highly effective".

Weight also doesn't tell the whole story. The people don't get any better, they get (more) starved in addition to staying obese.

It's a disease with another cause, hunger is only a symptom.

Too much money has been wasted on proving and "educating" people that it's just overeating, while there is an overwhelming amount of evidence to the contrary.

The one that convinced me is horses. Horses get fat, and they need to wear a muzzle that makes eating difficult for them. Otherwise, they eat so much so fast that it literally kills them.

There seem to be AREAS that are affected and areas that are less affected. Either there are fat people in the area, or there are no fat peoplle in the area. People who move seem to quickly change weight to fit the local norm. There doesn't seem to be any clear correlation with dietary habits, or anything else that is commonly observed. The entire Japan appears to be spared.

It gets commonly missed that it isn't possible to get obese on purpose either. It's hard to eat more, and the body just seems to burn off the excess.


This is a load of bullshit man. Even the article you linked describes lying to his friends' parents to get a second dinner, being unable to have just one cookie etc.

The only way to get fat is to eat too much and anyone who really eats too much will get fat. There's a huge amount of people who simply lie or are ignorant about their food intake. Fat people falsely claiming they hardly eat anything but can't lose weight etc. Of course you lose weight if you don't eat. Your body can't create energy from nothing. Without energy you die.


That's not actually what the evidence says, overwhelmingly.

Share to share any of it?

Always a fair request. I don't know it well enough or have time at the moment, but afaik it's the medical consensus:

Obesity is a disease, (mostly) not a result of behavior. Eating less and/or more activity doesn't cure people; iirc bodies adjust to retain the same amount of fat, etc. under the new conditions.


Then how does ozempic, whose primary mechanism of action is to decrease appetite, work for obese people?

Yes, your body will compensate somewhat for caloric deficit, and yes, when you gain enough fat mass your adipocytes will divide, creating more/stronger hunger signals that encourage weight gain moreso than someone who was never obese.

But your body is not magic. If you feed it a sufficiently low amount of calories, it has to break down energy stores, e.g. fat, to make up the difference in energy requirements.


> Then how does ozempic, whose primary mechanism of action is to decrease appetite, work for obese people?

That is a very interesting question.

> your body is not magic.

But it is a complex, highly adaptable system. The simplistic formula of calorie input = output is highly misleading.

> If you feed it a sufficiently low amount of calories

Sure, if you starve yourself, you'll start transitioning to dust pretty soon.


Somewhere between obese and dust you'll eventually hit a healthy weight.

https://pmc.ncbi.nlm.nih.gov/articles/PMC2495396/


That's a report on one person under direct medical supervision. The general consensus, afaik, is that starving yourself doesn't work, at least not more than short term - the weight comes right back.

It is a disease as in “your metabolism is slow” so you need to cut food even more. It is a disease as “you have problem with controlling your impulses and therefore crave food”

Psychological diseases are not better or worse from psychical/metabolic ones. They are real, and for some of them we have or we develop medicine.

Nobody is claiming that obesity can’t be a result of a disease, but under the hood it always ends up as: calories surplus is stored as fat.


Slow metabolism is a bit of a myth. By that I mean that it's not strictly wrong to say someone has a slow metabolism, but metabolism is an expression of your activity level so what you're really saying is the person is sedentary. If the person starts being more active their metabolism will necessarily increase.

So, slow metabolism is not a disease, it's not a genetic disorder, it is simply a result of the fact that someone is spending too much time on the couch.

I think this gets lost a lot when people talk about "slow metabolism", they turn it into this thing they're just helpless to influence, like they're just cursed with a slow metabolism and that's that. It's not like that at all, which is why I don't like the term. It just hides the reality of the situation.


What is all that based on?

Knowledge and understanding.

So nothing.

I don't know where you get your science man but I'm about 100% sure what you just said is completely false. Not even remotely controversial just flat out wrong.

What I said is commonplace if you look around.

Yeah, beliefs commonly held by people who would rather make excuses than improve their lives.

It's just baseless nonsense. Doctors and researchers say otherwise.

And you still haven't found the time to show me any of them.

Show us a basis for what you say.

I asked first. You're the one claiming all this scientific and expert consensus. I'm just talking common sense stuff that pretty much everyone agree on. This is simply the basics of how the body works. I could take some time to find some sources but so could you and you aren't so why should I?

It's pretty clear that you're thoroughly convinced of your own bullshit anyway, if you had any interest at all in finding the truth you'd do some light googling and find that pretty much everything I'm saying is true. I'm not interested in wasting my time finding arbitrary sources for common knowledge that you're just going to ignore anyway.

You don't have to find sources for me, I know they don't exist and if you find anything it's going to be obvious bullshit anyway. There are no serious doctors, nutritionists nor researchers who have any doubt whatsoever regarding what the roles and relationships of food and fat are in the human body. You're obviously just delusional. So good luck with that, I hope you can get past your issues and improve your life some day.


You admitted to me a few days ago that you are so fat that it makes you miserable. If direct, personal experience with it not working doesn't convince you, nothing will.

Are you juggling two accounts?

Yeah I said I find it miserable to be moderately overweight. I never said being more active and eating less doesn't work. It works great when I do it. I was under 90kg last year after just a few months of being active and eating better. And when I stop being active and start eating too much food, I gain weight. Which is literally exactly what I'm saying. So, I have direct personal experience with my advice working exactly the way I'm telling you it does.

At this point I'm just saying the same shit I said in the other comment already. The fact that I find it hard to follow my own advice, which I just told you because I thought it might help get my point across, is completely irrelevant to whether the advice works.

Anyway I'm over this whole conversation at this point. Do and believe whatever you want. I've said what I wanted to say. If you don't believe me that's fine, I don't care.


Methylmercury cysteine is an extra amino acid, and obesity is indistinguishable from mild kwashiorkor.

You are simply wrong about how everything involved works. It's a diseased, swollen tissue, not "energy storage".


Lol you guys are unbelievable. Go to Google, type in kwashiorkor, go to images and tell me that's indistinguishable from your average fatass.

Let's say there is a new discovery tomorrow - there is a virus that lives in your mitochondria, and makes them unable to produce energy. We can make a vaccine against it, and nobody will ever get fat.

Would you be against the vaccine?


Why would I be against that? I'm not against ozempic either.

I'm just against people who throw their hands in the air, say "my fatness is a disease" and continue eating 4000 calories a day while hardly moving at all. And just to be clear I'm not against the fatness - if you want to be fat that's fine, I don't care. It's your life. And if you want to say it's a mental disorder that's fine too, addiction is real and I know first hand that it's hard to resist good food and get off the couch.

Just don't claim there's nothing to be done about it. There is. I and many people I know have successfully lost weight by eating less and moving more. I've also gained weight by eating too much and moving too little. Because that's literally how it works, for everyone in the entire world. Sure it's possible to have some disease or disorder that prevents you from gaining weight by preventing you from utilizing the calories in your food. Or parasites can steal your calories. But if you aren't eating, your body still needs energy. It can't just choose to not use energy, energy is required to live. Without energy the heart doesn't beat, the lungs don't breathe, the brain doesn't brain, the muscles don't work. It's not like the body's just wasting energy, it uses as much as it has to. It's a fine tuned machine. So it can't just use less - the only way to use less energy is to spend less by moving less. Maybe the body can reduce it slightly by adjusting organ activity and such, but not much.

This is why we breathe oxygen and exhale CO2. Oxygen is literally used to burn calories, CO2 is the product of that combustion. Just like in a fire. When you exert yourself the body is spending more energy so it needs more oxygen and produces more CO2, that's why we need to breathe faster and our heart beats faster to get the oxygen to where it's needed and get rid of all the CO2. When you relax, your pulse and breathing lowers because you're burning very little.

Now, with this understanding of basic body functions it's obvious that moving more and eating less is how you lose weight. There is no question about it, it's just clear as day and absolutely indisputable.


All right. I guess you're right then, and the entire world is lying and everybody wants nothing else than to eat more.

Entire world? Everybody? No, I think most people are completely aware of the link between overeating and overweight. If everyone around you agree that food intake and weight are entirely unrelated things then maybe you're just in some kind of echo chamber. Or maybe people just don't care enough to challenge your ideas. I don't know, but I do know for a fact that what I said earlier is true and that it is the overwhelming scientific consensus.

That's why common remedies for obesity are things like dieting, stomach reducing surgery to reduce capacity for food, and ozempic and similar drugs that reduce appetite. See how the common denominator here is less food? Diet for those who can do it that way, more drastic measures for those who struggle with self control. And of course all of these solutions work better when coupled with regular physical activity. Simply taking a daily walk for half an hour is a great way to burn some extra calories and get the heart pumping at least a little, this has many benefits beyond burning calories.

Trust me I know it's hard. I'm not in the shape I wish I was. It's a lot easier to order a pizza than go to the store, figure out what to make, buy ingredients and cook a heathy meal. And it's so nice just crushing half or more of a large pizza in one sitting. The amount of junk food i can eat before I feel full is way more than I should have. It's a lot easier to spend all day in front of the computer or on the couch than getting out and doing some exercise. It's hard to do the things I know I should do, when what I should do and what I want to do are so different. I know from experience that when you get going it's easier to keep it going but I've also fallen off the wagon a lot. And it's not like you just do it for a little while and you're good, it's a permanent lifestyle change. It takes months or years of dieting to get down to a normal weight, it's a huge task.

But if you don't even believe that this is the solution, which it unequivocally is by the way, then you're either going to waste your time and probably money on things that don't work or more likely just keep eating yourself into an early grave while telling yourself you're just unlucky.

And I think it's worth some negative social points for saying things that might upset some people on social media, if I can maybe influence someone to get their shit together and work towards a better life.

This isn't opinion, I am 100% sure about these things and I'm not paid to say them. I just want to help. Trust me, you can lose weight and eating less and moving more is the way to do it. Ozempic and similar drugs can help with that and there's no shame in using them. The only thing that matters is getting healthy.

Obesity is a deadly condition and it's miserable. Trust me I've been in great shape I know exactly what I'm missing. And I'm not even very overweight, I'm about 100kg and it's already miserable. I can't imagine what it must be like for someone to weigh 150+. Struggling to breathe, getting winded just from getting off the couch. It's no way to spend your limited time in this world.

Oh and I forgot to mention a cool fact in my previous comment: that CO2 you're breathing out - that is your fat. That's where your fat goes when you burn it, you literally breathe it out. And the carbs of course. Your body turns the food you eat into energy and CO2. Unless you eat too much, then it turns it into fat to store it for later.


Yes, you need to find other pleasures in life. Use the clearer head space to figure out the emotional reasons for enjoying food so much.

Or just spend a long time in the Netherlands and they can teach you how people who enjoy food are indulgent and weird and therefore bad.


That’s why I quit soylent.

Now all I eat is chicken, and potatoes (regular and sweet) with avocado oil, and drink water. Salt is a bit of a problem because I use too much.

Easy to lose weight or maintain it when you eat one meal a day ime


I get a lot of side effects on it, and during those side effects, yoghurt is about all I can stomach.

I feel that analysing details and consequences based on the article is premature and marginal. The reduction of 5-8% of medication using households is barely beyond measurable (we have higher variation by the season). Yet they use the words 'striking', 'steep'. Also saying 'clear changes' in one part then admitting 'the reduction becomes smaller over time' (without specifics this time). The highest decrease of 10% for savory snacks is also modest at most (e.g. still consuming 9 pack instead of 10 in a reference period. having nothing good to watch on TV might have higher effect).

The data might really be useful for the food industry once, but only after the usage of the medicine goes beyond 16% currently. 5-8% change, even 10%, for 16% of the population is tiny.

To me the study sounds desperate to project significance, using adjectives rather than data for seeking attention.


Considering that only one person in a household might have gone on a medication, these percentages are actually more sizable than they might seem.

It would have been useful if this were broken out differently, to highlight the different impact in single-person households and larger households.




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