You can do GPU passthrough in a Gnome box, as in, your VM can see the host's GPU (let's say Nvidia) and it works exactly the same as on the host? Or another metric is if you can run Photoshop in a VM with full hardware acceleration. I haven't tried Gnome box in particular, but this isn't what I'm seeing when I search.

Ah, yeah, seems like I was mistaken and maybe Red Hat's virt-manager was what I was thinking of.

virt-manager is a bit more involved than GNOME's Boxes, I'm not sure I could recommend it to someone that doesn't know what they're doing.

Yeah, reading your original comment I was about to go off until I saw GPU pass through with DRM software. Highly cursed.

Yep, regular VMs where you basically only care about the CPU and RAM are easy, provided nothing in the VM is trying to not run in a VM. USB and network emulation used to be jagged edges, but that was fixed. VirtualBox was my go-to. It never had great GPU support, but the rest was easy.

I'm pretty sure there are solutions to assign an entire GPU to a VM, which ofc is only useful if you have multiple. But those are specialized.