A particularly egregious example is that once you get a mortgage you'll get flooded with hundreds of letters over years bearing the name of your mortgage company in the top left corner of the window claiming to be extremely urgent. If you look closely at these mailers you'll note that the name of the mortgage company isn't quite where the return address should be, and if you open the mailer and read the fine print they do finally disclaim being the mortgage company, but they're intentionally designed to mislead you into thinking they're from your company in a way that really ought to be illegal but isn't.
I found a small trick that much of the most junky mail doesn't get delivered to business addresses, and so I forwarded all my mail to my business address. This worked for a little while, and greatly reduced the amount of junk mail I received. But the US post office only lets you forward for a limited amount of time (or makes you pay a ridiculously high price to keep doing it).
At that point, I just took down my mailbox and changed my address on all my bills and such to my work address. This lead to the USPS reporting to HUD that my house was abandoned. That got forwarded to the bank that holds my mortgage, who freaked out. I got them calmed down, but then went through a period of having to explain to quite a few people why I don't have a mailbox. I got accused of being selfish and of being a luddite. I got told it was illegal. I basically was shamed about it endlessly.
After ten years, I finally just put a mailbox back up at my house because my son, who just turned eighteen and was applying for credit cards and such, ran into issues where he couldn't receive them because he had no residential mailbox and the banks told him "tough luck".
Did not having a mailbox interfere with deliveries?
I'd guess that FedEx and UPS don't care, but many online sellers (such as Amazon) don't let you choose which carrier they use for your shipment and sometimes choose USPS.
If any piece of mail has “standard postage” stamped on it on the top right, throw it in the trash. Any legitimate mail has “first class” stamped on it.