According to NASA's own advisory panel, the chance of losing the crew on just the SLS/Orion portion of the mission (so not including the landing, Gateway, or the trip to and from the lunar surface) is 1 in 75. If you make the reasonable assumption that the landing is at least as risky as the trip over, you get a 1 in 30 chance the crew dies.
The Shuttle towards the end of its life had an estimated chance of loss of crew of 1 in 90, and two administrations decided that was untenable. The standard for missions to ISS is 1:250. If a goal of Artemis is to meet modern safety standards, it's falling way short.
IIRC from the Feynman apendix, Nasa claimed in the official reports that the SLS had 1/10.000 or 1/1.000.000 chance of failures, but the real numeber was close to 1/100.
If they now claim 1/75 in the official reports, I'm very worried.
The Shuttle towards the end of its life had an estimated chance of loss of crew of 1 in 90, and two administrations decided that was untenable. The standard for missions to ISS is 1:250. If a goal of Artemis is to meet modern safety standards, it's falling way short.