I'm asytigmatic, light on dark is fine (and what I use everywhere) as long as it isn't #fff on #000 I'm OK so lots of my setup is quite light grey on dark grey.
The thing that really makes a difference for me is screen resolution (or more accurately, pixels per inch) on a modern 27" 4K I have far far fewer issues than I had on a 1280x1024 17" LCD - part of that is improvements in brightness/contrast and the technology as well though.
The thing that really makes a difference for me is screen resolution (or more accurately, pixels per inch) on a modern 27" 4K I have far far fewer issues than I had on a 1280x1024 17" LCD - part of that is improvements in brightness/contrast and the technology as well though.